Biopolymeric Blenda Scaffolds with Incorporation of an Organic Compound with Potential Pharmacological Activity for Application as a Wound Dressing

Resumo

Cutaneous wounds caused by trauma, burns, or chronic diseases are challenges that tissue engineering seeks to address through innovative strategies to accelerate healing, using various resources and techniques such as hydrogels and 3D bioprinting. Among the materials used in this field, GelMA (methacrylated gelatin) stands out for its biocompatibility, biodegradability, and non-immunogenicity. Therefore, this study focused on GelMA at different concentrations (5%, 10%, and 15%) to evaluate its properties. Mechanical tests showed that higher concentrations increase the material’s strength by enhancing its molecular bonds, resulting in greater tension required for rupture of the dressing. Fourier-transform infrared spectroscopy (FTIR) confirmed the methacrylation reaction. The next step of the study is to evaluate infill patterns and biological properties, aiming to enhance the effectiveness of the dressings in wound healing.