Challenges in the Development Process of Lipid Nanoemulsions for Parenteral Nutrition

Resumo

Lipid emulsions (ELP) used in parenteral nutrition represent a complex pharmaceutical formulation. These emulsions serve as vital sources of energy, essential fatty acids, and fat-soluble vitamins in nutritional therapy regimens. Therefore, following a systematic approach in the development process is crucial to ensure the safety of ELP. With this objective in mind, our study aimed to survey the stages involved in the development process of lipid nanoemulsions applied in parenteral nutrition and to identify the primary needs and challenges encountered throughout this process. Consequently, our analysis revealed 10 stages in the Product Development Process (PDP) and identified 20 specific needs that characterize the development of lipid nanoemulsions for parenteral nutrition. These identified needs offer valuable insights for future research endeavors to enhance the development of parenteral diets.