JOURNAL OF BIOENGINEERING, TECHNOLOGIES AND HEALTH

Biopolymeric Blenda Scaffolds with Incorporation of an Organic Compound with Potential Pharmacological Activity for Application as a Wound Dressing

2025-09-13T03:06:18+00:00

Cutaneous wounds caused by trauma, burns, or chronic diseases are challenges that tissue engineering seeks to address through innovative strategies to accelerate healing, using various resources and techniques such as hydrogels and 3D bioprinting. Among the materials used in this field, GelMA (methacrylated gelatin) stands out for its biocompatibility, biodegradability, and non-immunogenicity. Therefore, this study focused on GelMA at different concentrations (5%, 10%, and 15%) to evaluate its properties. Mechanical tests showed that higher concentrations increase the material’s strength by enhancing its molecular bonds, resulting in greater tension required for rupture of the dressing. Fourier-transform infrared spectroscopy (FTIR) confirmed the methacrylation reaction. The next step of the study is to evaluate infill patterns and biological properties, aiming to enhance the effectiveness of the dressings in wound healing.

Beyond the Lesion: How Neurobypass 1.0 Transforms Post-Stroke Rehabilitation for Motor Recovery

2025-09-13T03:06:15+00:00

Stroke is one of the leading causes of death and functional disability in Brazil, significantly impacting survivors' quality of life. The Neurobypass 1.0 project proposes an innovative approach to post-stroke motor rehabilitation through a neuro-controlled hand and wrist orthosis. Developed by SENAI CIMATEC in partnership with CEPRED, the device uses brain-computer interface (BCI), virtual reality (VR), and additive manufacturing (3D printing) to promote engagement, customization, and neuroplasticity stimulation. A systematic review identified evidence for the efficacy of BCI and AR orthoses in enhancing function and motivation in patients with hemiparesis. A randomized clinical trial protocol was designed to assess motor, emotional, and motivational outcomes of the intervention. Expected results include functional hand recovery, reduced depressive symptoms, and greater independence. The initiative highlights Brazil's potential as a reference in accessible assistive technologies.

Development of Novel Bioceramic Cements

2025-09-13T03:06:13+00:00

Bioceramic cements, composed of calcium and strontium silicates and aluminates, have gained prominence in orthopedics and dentistry due to their bioactive and biocompatible properties. These materials are effective in bone regeneration and root canal sealing, overcoming the limitations of traditional cements such as Mineral Trioxide Aggregate (MTA). The synthesis of bioceramics is performed using the solution combustion synthesis (SCS) method, which enables the production of homogeneous and highly pure powders. This process enhances control over crystalline phases and increases the materials' reactivity. The combination of different compounds and the use of this synthesis method allow for the optimization of properties such as mechanical strength and bioactivity. Thus, these materials offer a promising alternative for developing more effective and safer solutions for regenerating mineralized tissue.

Application of Bioinformatics Tools in the Optimization of mRNA Sequences Focused on Vaccine and Therapeutic Development

2025-09-13T03:06:11+00:00

This in silico study explored the optimization of therapeutic RNA modeling using AI (AlphaFold3, Boltz-1, Chai-1). An assembly method combined high-confidence regions to model complex sequences. Quality was evaluated using five standardized metrics (secondary structure, stability, translation, immunogenicity, and production). Simulations and bioinformatics analyses were used to assess the stability and function of the optimized structures. The objective was to develop more accurate and comparable modeling methodologies for therapeutic RNA design, while recognizing the need for subsequent experimental validation.

Bioprospection of Enzyme-Producing Bacteria Applicable to the Hydrolysis of Cacao Biomass (Theobroma cacao)

2025-09-13T03:06:09+00:00

This article examines the potential of cocoa agro-industrial waste for biofuel production, aiming to provide a sustainable alternative to fossil fuels and promote waste reuse. It explores the bioprospecting of cellulase-producing microorganisms in cocoa-growing areas, focusing on the microbial diversity of Brazilian soil and its role in lignocellulose degradation. The method involved the induction of cellulolytic activity in a medium with CMC, isolation and characterization of the bacteria, production of an enzymatic extract, and quantification of reducing sugars via the DNSA method. The objective is to identify efficient cellulase-producing microorganisms to optimize the conversion of cocoa residues into biofuel, promoting a greener economy in the energy sector. A total of four bacterial strains (3A, 5, 6, and 8) were isolated, Gram staining was performed for each, and sugar quantification yielded the following enzymatic activity results: strain 3A – 0.42; 5 – 0.2; 6 – 0.24; and 8 – 0.27 U/mL.

Implementation of Anti-Fouling Tests with Copper Sulphate Pentahydrate Using the Coral Flavia gravida (Cnidara, Scleractinia)

2025-09-13T03:06:06+00:00

The use of antifouling compounds in paints on ships and oil platforms has caused environmental damage to marine species. Thus, the demand for environmentally friendly compounds and technologies has increased. The objective of this article was to perform toxicological experiments with the antifouling biocide copper sulfate pentahydrate to identify concentrations that have the least impact on the native coral Favia gravida. The acute test showed mortality at concentrations of 0.02 and 0.025 mg/mL, although reactions in mobility, cilia movement, and initial development were observed at concentrations above 0.01 mg/mL. The chronic test showed continued development only in the control and at a concentration of 0.005 mg/mL. The high mortality rate in the control group indicates the need for further testing. This is the first toxicological test with an antifouling agent in F. gravida.

Development of a Side-View System for Atomic Force Microscopy (AFM)

2025-09-13T03:05:41+00:00

This study presents the development of a side-view imaging system for atomic force microscopy (AFM). The system consists of a monochromatic camera, two lenses, a light source, and image processing software. Six qualitative tests were conducted to evaluate the system's field of view and resolution. The field of view tests used a target positioned both horizontally and vertically. In contrast, the high-resolution test was conducted with the target fixed horizontally and an exposure time of 3,000 milliseconds in both tests. The results allowed the evaluation of the optical system's performance. They demonstrated its feasibility for side imaging in the AFM system under development at the Optics Laboratory, ensuring greater precision in the probe's approach to the sample.

FBG-Baesd Soft Probe for Measurement of Temperature Using Strain Decoupling Technique

2025-09-13T03:05:39+00:00

This study explores the use of Fiber Bragg Grating (FBG) sensors encapsulated in stainless steel for precise temperature measurements in a soft probe applicati on. Encapsulation enhances temperature sensitivity while minimizing strain interference, a common challenge in FBG sensor applications. Experimental results showed minimal wavelength shifts and temperature errors, demonstrating the effectiveness of the metallic capillary in decoupling strain effects from temperature measurements. The calibration curve confirmed high temperature sensitivity and low strain sensitivity. This method offers a reliable solution for precise temperature measurements in environments where strain can introduce measurement noise.

Innovation in Low-Cost Sensor for Water Turbidity Assessment

2025-09-13T03:05:37+00:00

This work emphasizes the importance of monitoring water quality through a low-cost turbidity sensor to support environmental management. Using LDR sensors and an Arduino, the project determines the ideal wavelength and establishes the calibration curve. The sensor operates automatically, performing color scanning and selecting the wavelength most sensitive to variations in water turbidity. Data analysis revealed a calibration curve with a coefficient of determination (R²) of 0.995, highlighting the sensor's high precision. Turbidity quantification is achieved through nephelometric (90°) and turbidimetric (180°) methods, optimizing sensor configuration and wavelength to obtain the best measurements.

Meshless Simulation Software Applied to the Preliminary Design Phase of the Product Development Process

2025-09-13T03:05:35+00:00

The study involves the construction and validation of a product development method using meshless simulation software in the preliminary phase of a project, for the structural and functional evaluation of the concept selected in the conceptual phase, to obtain a more robust concept for the detailed phase. This enhances the efficiency of project development, significantly reducing costs and computational time. Two studies will be carried out using meshless software and finite elements to validate the proposed method. Through computational cost evaluation, it was observed that using the meshless software application method in the preliminary phase resulted in a reduction of approximately 19 times in the time invested in CAE analysis during the product's preliminary development phase.

Technological Mapping of Fermented Cocoa Honey Beverages Using Kefir Grains with Functional Effect

2025-09-13T03:05:33+00:00

Cocoa honey is a mucilaginous and bittersweet byproduct of the chocolate industry. To increase its added value, producers and researchers have explored new applications such as fermented beverages. Water kefir grains, used in fermentation processes, exhibit functional potential due to the presence of probiotic microorganisms. This study mapped patents related to the production of functional beverages combining cocoa, honey, and kefir, using the Derwent Innovation Index (DII), accessed through Universidade SENAI CIMATEC in Salvador, Brazil. Results revealed a technological gap, with few patents combining these elements, indicating opportunities for research and development of new products. The proposal aligns with global trends in sustainable reuse of byproducts, offering a beverage with attractive organoleptic characteristics and health benefits.

Energy Recovery from Municipal Solid Waste (Waste to Energy) in Salvador and Feira de Santana, Bahia, Brazil

2025-09-13T03:05:15+00:00

The generation of municipal solid waste (MSW) is closely related to the number of inhabitants and their income levels. Population growth increases MSW generation, causing economic, social, and environmental problems that the energy recovery of this biomass could mitigate. This solution is not only energetically viable but also economically attractive and environmentally beneficial, as it contributes to reducing the generation of greenhouse gases (GHGs) in landfills, thereby extending the useful life of these facilities. This work sought to identify in the literature the necessary characteristics for energy recovery from MSW and the properties of such waste in the metropolitan regions of Salvador and Feira de Santana, Bahia. Based on this analysis, new studies will be developed to investigate the composition, calorific value, and moisture content of the waste, as well as to assess the feasibility of implementation in other regions of the state. The method used included a literature review and consultation of relevant institutions in the field.

Identification and Quantification of Nitrogen Flow in the Sanitation System of the Identity Territory of Southernmost Bahia

2025-09-13T03:05:11+00:00

Sewage is a rich source of nitrogen, phosphorus, and potassium, and its efficient management can reduce pollution, promote sustainable water use, and enable its use as fertilizer. Material Flow Analysis (MFA) has been effective in managing these nutrients within the sanitation system. This study conducted a Nitrogen Flow Analysis (NFA) in the Identity Territory of the Southernmost Region of Bahia (TI07) for 2022, revealing that 46.31% of the sewage is discharged directly into the hydrosphere, possibly contaminating water bodies. Therefore, technologies such as vermifilters and green septic systems are recommended for treating sewage and recycling nitrogen for use as fertilizer or in food production. The NFA also showed that waste management accumulated 23.49% of the system's total nitrogen, highlighting the potential for composting, fertilizer supply, and strengthening local family farming.

Development of an Artifact to Enhance the Resilience of Low-Carbon Decentralized Energy Solutions in Remote Regions

2025-09-13T03:05:09+00:00

This study aimed to assess the development of an artifact that supports the resilience of decentralized low-carbon energy generation solutions. We applied the Design Science Research (DSR) method to guide the construction of the artifact, considering the resilience of decentralized low-carbon energy generation solutions, local vulnerabilities, and social technologies. In this context, this research sought to characterize the stages of artifact construction and align them with Sustainable Development Goal (SDG) 7, which aims to ensure access to clean and affordable energy.

The Importance of Validating New in vitro Medical Devices

2025-09-13T03:05:13+00:00

Currently, technological innovations are increasingly gaining ground in all fields, and especially in medicine, the validation process is one of the essential requirements for the approval of new medical devices (MDs) and in vitro diagnostic devices (IVDs). For a new device to be introduced into the market, it must meet specific requirements, and it is in this context that validation emerges. All IVDs and MDs must be approved by the National Health Surveillance Agency (ANVISA) or the relevant health authority of the country to ensure that the device is safe and effective for the population, and that its use will cause minimal harm compared to the benefits it can bring. In this context of Health Technology Assessment (HTA), this study aims to highlight, through a literature review, the importance of the validation process for IVDs and its impact on the market and the healthcare network.

A Review of Different Methods for Superhydrophobic Textiles and Fabrics Using Nanotechnology

2025-09-13T03:05:08+00:00

Recent developments in superhydrophobic textiles involve many technologies and fields of knowledge, such as textile engineering, surface treatments, and nanomaterials. Several methods can be employed to achieve the superhydrophobicity of fabrics, including dip coating, in situ growth, the sol-gel approach, and immersion. This review presents each method and investigates its peculiarities, correlating it with reagents and results. A brief conclusion is also presented with future perspectives. The P.R.I.S.M.A. (Preferred Reporting Items for Systematic Review and Meta-Analysis) protocol was followed, aiming to select the most relevant papers for the area and to evaluate the results accordingly. Selected keywords were superhydrophobic AND [textile OR fabric OR cloth] AND [coating OR immersion OR gel]. Furthermore, only articles published between 2019 and 2024, in the English language, were selected.